Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Enteric fever, a non-specific, systemic infection caused by S. Typhi or Paratyphi A, B or C, is common in resource-limited regions of the world, where poor sanitation infrastructure facilitates faeco-oral transmission. Prompt treatment with appropriate antibiotics minimises illness severity, but presentation to health care facilities is often delayed because of the non-specific nature of the symptoms and the lack of reliable diagnostic tests. Disease prevention requires significant investment in provision of clean water and sanitation in the long term; vaccination offers a more realistic strategy for medium term control. However, implementation of existing vaccines and development of more efficacious vaccines has been hindered by the lack of an established correlate of protection and under appreciation of the true disease burden. Human microbial infection studies could provide a vehicle for the rapid evaluation of novel vaccines and investigation of the immunobiology of enteric infection.

Original publication

DOI

10.1016/j.jinf.2013.09.013

Type

Journal

J Infect

Publication Date

01/2014

Volume

68 Suppl 1

Pages

S38 - S50

Keywords

Challenge studies, Controlled human infection, Disease control, Enteric fever, Paratyphoid, S. Paratyphi, S. Typhi, Typhoid, Vaccine, Anti-Bacterial Agents, Humans, Salmonella Vaccines, Sanitation, Typhoid Fever