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The relationship between the function of human immunodeficiency virus (HIV)-specific CD8 T-cell responses and viral load has not been defined. In this study, we used a panel of major histocompatibility complex class I tetramers to examine responses to frequently targeted CD8 T-cell epitopes in a large cohort of antiretroviral-therapy-naïve HIV type 1 clade C virus-infected persons in KwaZulu Natal, South Africa. In terms of effector functions of proliferation, cytokine production, and degranulation, only proliferation showed a significant correlation with viral load. This robust inverse relationship provides an important functional correlate of viral control relevant to both vaccine design and evaluation.

Original publication

DOI

10.1128/JVI.01754-06

Type

Journal article

Journal

J Virol

Publication Date

01/2007

Volume

81

Pages

434 - 438

Keywords

CD8-Positive T-Lymphocytes, Cell Proliferation, Cohort Studies, Epitopes, T-Lymphocyte, HIV Antigens, HIV Infections, HIV-1, Histocompatibility Antigens Class I, Humans, Interferon-gamma, Interleukin-2, South Africa, Viral Load