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Respiratory syncytial virus (RSV) infection is a major cause of morbidity in childhood worldwide. The first human RSV-specific cytotoxic T-lymphocyte epitope to be defined is described. This HLA B7-restricted epitope in nucleoprotein (NP) was detectable in four healthy, B7-positive adult subjects using B7-RSV-NP tetrameric complexes to stain CD8(+) T cells.

Type

Journal article

Journal

J Virol

Publication Date

08/2000

Volume

74

Pages

7694 - 7697

Keywords

Adult, Enzyme-Linked Immunosorbent Assay, Epitopes, T-Lymphocyte, Flow Cytometry, HLA-B7 Antigen, Humans, Respiratory Syncytial Virus Infections, Respiratory Syncytial Viruses, T-Lymphocytes, Cytotoxic