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HLA-B35 has consistently been associated with rapid HIV disease progression, particularly alleles of the Px group. As B35 is the most prevalent HLA-B in Mexico, we investigated HIV disease outcome in relation to HLA expression in a large cohort (n=976) of Mexicans. Contrary to the previous studies, no impact on viral load or CD4 cell count was observed in association with the B35 PY/Px groups. However, we observed differences in HIV disease outcome associated with specific HLA-B35 alleles.

Original publication

DOI

10.1097/QAD.0000000000000322

Type

Conference paper

Publication Date

17/07/2014

Volume

28

Pages

1687 - 1690

Keywords

Alleles, CD4 Lymphocyte Count, Cohort Studies, HIV Infections, HLA-B35 Antigen, Humans, Mexico, Treatment Outcome, Viral Load