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We have previously shown that Vpu is rarely targeted by HIV-1-specific cytotoxic T lymphocytes (CTL). The present report extends these findings and describes the characterization of the first CTL epitope within HIV-1 Vpu, identified in an individual with long-term non-progressive HIV-1 infection. The epitope was shown to be highly conserved among HIV clade B sequences and is restricted by HLA-A*3303, an HLA allele commonly seen in Asian and west-African populations.

Type

Journal article

Journal

AIDS

Publication Date

03/05/2002

Volume

16

Pages

1071 - 1073

Keywords

Amino Acid Sequence, Consensus Sequence, Cytotoxicity, Immunologic, Disease Progression, HIV Infections, HIV Long-Term Survivors, HIV-1, HLA-A Antigens, Human Immunodeficiency Virus Proteins, Humans, Molecular Sequence Data, Peptide Fragments, T-Lymphocytes, Cytotoxic, Viral Regulatory and Accessory Proteins