Abo Y-N., Curtis N., Osowicki J., Haeusler G., Purcell R., Kadambari S., De Wachter M., Vanden Driessche K., Dekeyzer S., Coleman L., Crawford N., Graham S., Marais B., Gwee A.

Paradoxical reactions in central nervous system tuberculosis (CNS-TB) are associated with significant morbidity and mortality. We describe 4 HIV-uninfected children treated for CNS-TB with severe paradoxical reactions unresponsive to corticosteroids. All made recovery after treatment with infliximab, highlighting the safety and effectiveness of infliximab for this complication, and need for prospective trials.

Infliximab for Paradoxical Reactions in Pediatric Central Nervous System Tuberculosis.

Abo Y-N., Curtis N., Osowicki J., Haeusler G., Purcell R., Kadambari S., De Wachter M., Vanden Driessche K., Dekeyzer S., Coleman L., Crawford N., Graham S., Marais B., Gwee A.

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