Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Fourteen children with no detectable bactericidal antibody response to a first dose of meningococcal C conjugate vaccine at 4 years of age were given a booster dose of the same vaccine 2 years later. A rapid 1000-fold rise in postimmunization bactericidal antibody titers, a measured either 7 or 14 days later, suggested previous immunologic priming.


Journal article


Pediatr Infect Dis J

Publication Date





659 - 661


Antibodies, Bacterial, Antibody Formation, Child, Child, Preschool, Enzyme-Linked Immunosorbent Assay, Female, Follow-Up Studies, Humans, Immunization Schedule, Immunization, Secondary, Immunologic Memory, Male, Meningococcal Infections, Meningococcal Vaccines, Neisseria meningitidis, Probability, Prospective Studies, Sampling Studies, Sensitivity and Specificity, Time Factors