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Heterologous prime-boost strategies are known to substantially increase immune responses in viral vectored vaccines. Here we report on safety and immunogenicity of the poxvirus Modified Vaccinia Ankara (MVA) vectored vaccine expressing four Mycobacterium avium subspecies paratuberculosis antigens as a single dose or as a booster vaccine following a simian adenovirus (ChAdOx2) prime. We demonstrate that a heterologous prime-boost schedule is well tolerated and induced T-cell immune responses.

Original publication

DOI

10.3390/vaccines9030262

Type

Journal article

Journal

Vaccines (Basel)

Publication Date

16/03/2021

Volume

9

Keywords

T-Cell, vaccine, viral vector