Cell-penetrating peptides
RAZ R., WOOD M., El Andaloussi S., MCCLOREY G., Manzano R., Gait MJ., Godfrey C., ARZUMANOV A., O'Donovan L.
the present invention relates to peptides, in particular cell-penetrating peptides, having a first hydrophobic domain positioned at the C-terminus of the peptide and a second hydrophobic domain positioned at the N-terminus of the peptide, and to conjugates of such cell-penetrating peptides with a therapeutic molecule. The present invention further relates to use of such peptides or conjugates in methods of treatment or as a medicament, especially in the treatment of genetic disorders and in particular muscular dystrophies such as Duchenne muscular dystrophy.