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The hypothesis that the intrapatient emergence of cytotoxic T-lymphocyte escape variants contributes to the evolution of human immunodeficiency virus type 1 at the population (interpatient) level was tested using the HLA-A*0201-restricted gag p17 epitope SLYNTVATL. Using a simple experimental design, we investigated the evolutionary processes operating within this epitope among patients while compensating for the confounding influence of intrapatient natural selection. Using this approach, we revealed a pattern of A*0201-driven escape within patients, followed by the sustained transmission of these escape variants among patients irrespective of their HLA type.

Original publication

DOI

10.1128/JVI.79.14.9363-9366.2005

Type

Journal article

Journal

J Virol

Publication Date

07/2005

Volume

79

Pages

9363 - 9366

Keywords

Acquired Immunodeficiency Syndrome, Amino Acid Sequence, Epitopes, T-Lymphocyte, HIV-1, HLA-A Antigens, Humans, Molecular Sequence Data, Selection, Genetic, T-Lymphocytes, Cytotoxic