Effect of a quadrivalent meningococcal ACWY glycoconjugate or a serogroup B meningococcal vaccine on meningococcal carriage: An observer-blind, phase 3 randomised clinical trial
Read RC., Baxter D., Chadwick DR., Faust SN., Finn A., Gordon SB., Heath PT., Lewis DJM., Pollard AJ., Turner DPJ., Bazaz R., Ganguli A., Havelock T., Neal KR., Okike IO., Morales-Aza B., Patel K., Snape MD., Williams J., Gilchrist S., Gray SJ., Maiden MCJ., Toneatto D., Wang H., McCarthy M., Dull PM., Borrow R.
Background Meningococcal conjugate vaccines protect individuals directly, but can also confer herd protection by interrupting carriage transmission. We assessed the effects of meningococcal quadrivalent glycoconjugate (MenACWY-CRM) or serogroup B (4CMenB) vaccination on meningococcal carriage rates in 18-24-year-olds.