Evaluation of Acute and Convalescent Antibody Concentration Against Pneumococcal Capsular Polysaccharides for the Diagnosis of Pneumococcal Infection in Children with Community-Acquired Pneumonia.
Carter MJ., Shrestha S., O'Reilly P., Gurung P., Gurung M., Thorson S., Kandasamy R., Voysey M., O'Mahony E., Kelly S., Ansari I., Shah G., Amatya P., Tcherniaeva I., Berbers G., Murdoch DR., Pollard AJ., Shrestha S., Kelly DF., on behalf the PneumoNepal Study Group .
We evaluated whether the quantification of IgG to pneumococcal capsular polysaccharides is an accurate diagnostic test for pneumococcal infection in children with pneumonia in Nepal. Children with pneumococcal pneumonia did not have higher convalescent, or higher fold change, IgG to pneumococcal polysaccharides than children with other causes of pneumonia. Caution is needed in interpreting antibody responses in pneumococcal infections.