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Sorcha O'Byrne

BSc ARCS


DPhil Student

Main research interest: the role of trisomy 21 (T21) in B-lymphopoiesis and acute lymphoblastic leukaemia (ALL).

I joined Prof. Irene Roberts lab in October 2015 and am co-supervised by Dr. Anindita Roy. Both labs are focussed on understanding haematopoiesis and the molecular mechanisms that contribute to leukaemogenesis in children.  

Currently funded by the Department of Paediatrics and The Alexander Thatte Fund, the main focus of my D.Phil. is to decipher the molecular mechanisms that underlie B-lymphopoiesis. Understanding the ontogeny of B-lymphopoiesis and what happens in T21 is likely to be key in understanding both ALL associated with Down Syndrome (DS-ALL) and ALL in children without Down Syndrome. 

 

Publications:

  • Roy, A., Bystry, V., Bohn, G., Goudevenou, K., Reigl, T., Papaioannou, M., Krejci, A., O’Byrne, S., Chaidos, A., Grioni, A., Darzentas, N., Roberts, I.A.G., Karadimitris, A., 2017. High resolution IgH repertoire analysis reveals fetal liver as the likely origin of life-long, innate B lymphopoiesis in humans. Clinical Immunology 183, 8–16. doi:10.1016/j.clim.2017.06.005
  • Kerry, J., Godfrey, L., Repapi, E., Tapia, M., Blackledge, N.P., Ma, H., Ballabio, E., O’Byrne, S., Ponthan, F., Heidenreich, O., Roy, A., Roberts, I., Konopleva, M., Klose, R.J., Geng, H., Milne, T.A., 2017. MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia. Cell Rep 18, 482–495. doi:10.1016/j.celrep.2016.12.054
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