Marcin Pekalski
PhD MRes
Principal Scientist
Immunology, host microbiota interactions, immunotherapy
My research interest gravitates towards the host microbial interaction and mechanisms governing induction of the immune tolerance in the first years of human life.
Recent publications
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Low-dose IL-2 reduces IL-21+ T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes.
Journal article
Zhang J-Y. et al, (2022), Nat Commun, 13
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Thymocyte regulatory variant alters transcription factor binding and protects from type 1 diabetes in infants.
Journal article
Sandholm N. et al, (2022), Sci Rep, 12
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Supplementation with Bifidobacterium longum subspecies infantis EVC001 for mitigation of type 1 diabetes autoimmunity: the GPPAD-SINT1A randomised controlled trial protocol.
Journal article
Ziegler A-G. et al, (2021), BMJ Open, 11
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Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp620 Risk Allele Drive the Expansion of FOXP3+ Regulatory T Cells and PD-1 Expression.
Journal article
Ferreira RC. et al, (2019), Front Immunol, 10
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A long-lived IL-2 mutein that selectively activates and expands regulatory T cells as a therapy for autoimmune disease.
Journal article
Peterson LB. et al, (2018), J Autoimmun, 95, 1 - 14
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The DILfrequency study is an adaptive trial to identify optimal IL-2 dosing in patients with type 1 diabetes.
Journal article
Seelig E. et al, (2018), JCI Insight, 3
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Capturing the systemic immune signature of a norovirus infection: an n-of-1 case study within a clinical trial
Journal article
Cutler AJ. et al, (2017), Wellcome Open Research, 2, 28 - 28
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A rare IL2RA haplotype identifies SNP rs61839660 as causal for autoimmunity
Journal article
Rainbow DB. et al, (2017)
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Capturing the systemic immune signature of a norovirus infection: an n-of-1 case study within a clinical trial.
Journal article
Cutler AJ. et al, (2017), Wellcome Open Res, 2
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Capturing the systemic immune signature of a norovirus infection: an n-of-1 case study within a clinical trial.
Journal article
Cutler AJ. et al, (2017), Wellcome open research, 2
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Investigation of soluble and transmembrane CTLA-4 isoforms in serum and microvesicles.
Journal article
Esposito L. et al, (2014), J Immunol, 193, 889 - 900
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Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function.
Journal article
Garg G. et al, (2012), J Immunol, 188, 4644 - 4653
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Reduced expression of IFIH1 is protective for type 1 diabetes.
Journal article
Downes K. et al, (2010), PLoS One, 5
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OXIDATIVE STRESS INDUCES EPITHELIAL TO MESENCHYMAL TRANSITION IN HUMAN LUNG EPITHELIAL CELLS THROUGH TRANSFORMING GROWTH FACTOR BETA AND INTEGRIN BETA6-DEPENDENT MECHANISM
Conference paper
Gorowiec MR. et al, (2008), THORAX, 63, A45 - A45