Contact information
francois.halloy@paediatrics.ox.ac.uk
francois.halloy@idrm.ox.ac.uk
https://orcid.org/0000-0003-2973-5820
Institute of Developmental and Regenerative Medicine (IDRM), Old Road Campus, Oxford OX3 7TY
Research groups
François Halloy
Post-Doctoral Research Fellow
I joined the Wood laboratory as a postdoctoral research scientist in January 2021. I hold MSc degrees in chemistry and biology from the National Graduate School of Chemistry of Montpellier (France) and a PhD degree from the ETH Zurich (Switzerland). My research interests lie at the nexus of chemistry and biology, with a concentration on the development of oligonucleotide formulations for genetic disorders. In the Wood group, my focus is on the development of molecular shuttles for the delivery of oligonucleotide therapeutics through the blood-brain barrier.
Colleges
Recent publications
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Efficient Synthesis of 2'-O-Methoxyethyl Oligonucleotide-Cationic Peptide Conjugates.
Journal article
Halloy F. et al, (2021), ChemMedChem, 16, 3391 - 3395
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Repurposing of glycine transport inhibitors for the treatment of erythropoietic protoporphyria.
Journal article
Halloy F. et al, (2021), Cell Chem Biol, 28, 1221 - 1234.e6
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RNA-PROTACs: Degraders of RNA-Binding Proteins.
Journal article
Ghidini A. et al, (2021), Angew Chem Int Ed Engl, 60, 3163 - 3169
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Delivery of oligonucleotides to bone marrow to modulate ferrochelatase splicing in a mouse model of erythropoietic protoporphyria
Journal article
Halloy F. et al, (2020), Nucleic Acids Research, 48, 4658 - 4671
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Delivery of oligonucleotides to bone marrow to modulate ferrochelatase splicing in a mouse model of Erythropoietic Protoporphyria
Preprint
Halloy F. et al, (2020)
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Increased Affinity of 2′-O-(2-Methoxyethyl)-Modified Oligonucleotides to RNA through Conjugation of Spermine at Cytidines
Journal article
Decuypere E. et al, (2019), Helvetica Chimica Acta, 102
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Delta-aminolevulinic acid synthase 2 expression in combination with iron as modifiers of disease severity in erythropoietic protoporphyria
Journal article
Barman-Aksözen J. et al, (2019), Molecular Genetics and Metabolism, 128, 304 - 308
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Chemical synthesis of long RNAs with terminal 5′-phosphate groups
Journal article
Pradère U. et al, (2017), Chemistry - A European Journal, 23, 5210 - 5213