PhD, Bsc (Hons)
Postdoctoral research scientist in muscle biology
I completed my Ph.D. program at University of New South Wales, Australia in transcription factor biology under the mentorship of Professor Merlin Crossley in 2016, where I studied the design of artificial DNA binding factors and investigated how transcription factors find their targets in vivo.
I joined Matthew’s group in 2017 as a postdoctoral research scientist in muscle biology. Here I am studying transcriptional regulators involved in muscle regeneration and in collaboration with Dr. Carlo Rinaldi, I am also investigating the role of an androgen receptor isoform in the pathogenesis of Spinal bulbar muscular atrophy (SBMA).
Directing an artificial zinc finger protein to new targets by fusion to a non-DNA-binding domain
Lim WF. et al, (2016), Nucleic Acids Res, 44, 3118 - 3130
Differential regulation of the α-globin locus by Krüppel-like Factor 3 in erythroid and non-erythroid cells.
Funnell APW. et al, (2014), BMC Mol Biol, 15
Regions outside the DNA-binding domain are critical for proper in vivo specificity of an archetypal zinc finger transcription factor
Burdach J. et al, (2014), Nucleic Acids Res, 42, 276 - 289
Loss of Kruppel-like factor 3 (KLF3/BKLF) leads to upregulation of the insulin-sensitizing factor adipolin (FAM132A/CTRP12/C1qdc2)
Bell-Anderson KS. et al, (2013), Diabetes, 62, 2728 - 2737