Fibulin-2, an extracellular matrix protein expressed by normal epithelia, was found to be down-regulated in several breast cancer cell lines. Fibulin-2 protein expression was also decreased in breast cancer tissue samples as evaluated by immunohistochemistry. Reintroduction of Fibulin-2 into breast cancer cell lines that do not express Fibulin-2 reduced cancer cell motility and invasion in vitro but had no effect on cell growth and adhesion properties. Together with evidence that Fibulin-2 contributes to wound healing and inhibits smooth muscle cell migration, our findings suggest that loss of Fibulin-2 expression may facilitate migration and invasion in breast cancer.
Journal article
2007-05-01T00:00:00+00:00
170
1535 - 1545
10
Blotting, Western, Breast Neoplasms, Calcium-Binding Proteins, Cell Adhesion, Cell Line, Tumor, Cell Movement, Disease Progression, Female, Gene Expression, Gene Expression Profiling, Humans, Immunohistochemistry, Oligonucleotide Array Sequence Analysis, RNA, Messenger, Reverse Transcriptase Polymerase Chain Reaction