Germline variants in predisposition genes in children with Down syndrome and acute lymphoblastic leukemia.

Winer P., Muskens IS., Walsh KM., Vora A., Moorman AV., Wiemels JL., Roberts I., Roy A., de Smith AJ.

Rare and pathogenic germline variants, including in IKZF1, contribute to acute lymphoblastic leukemia in children with Down syndrome.

DOI

10.1182/bloodadvances.2019001216

Type

Journal article

Publication Date

2020-02-25T00:00:00+00:00

Volume

4

Pages

672 - 675

Total pages

3

Keywords

Child, Down Syndrome, Germ Cells, Germ-Line Mutation, Humans, Precursor Cell Lymphoblastic Leukemia-Lymphoma

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