Healthcare Translation Research Group
The Healthcare Translation Group specialises in the evaluation and development of processes impacting the translation of scientific innovations into clinical and commercial outcomes. The group researches and develops novel therapeutic and diagnostic platforms. It also works in the complementary field of digital health technologies which are utilised to support the rapid deployment of the above platforms. Supported by international philanthropic and industrial funders and research bodies, the Healthcare Translation Group undertakes interdisciplinary research delivering real-world impact in regenerative medicine (cell, gene, immuno-therapies and tissue engineering), vaccines, gene editing technologies and digital health – this includes medicines optimisation and supply chain security.
Advanced therapeutics clinical translation and cell therapy commercialisation
Advanced therapies, such as cell and gene therapies, are a new therapeutic modality which have potential to offer treatment or cures for currently untreatable diseases. This therapeutic strategy is very young in comparison to standard chemical-based drugs, and therefore few are currently established on the market.
Disease phenotype modeling
Mathematical modeling allows researchers to investigate the impact of certain therapeutic strategies on a hypothetical patient cohort, informing decision making.
Intellectual property landscaping
Intellectual property (IP) is of fundamental importance to medicinal product development. IP landscaping is a method by which information about IP can be gathered, and can provide valuable insight into the activity of other research groups or the progression of research areas as a whole.
Machine learning for drug prioritization
The drug development process is increasingly costly, leading to a pharmaceutical industry that many describe as unsustainable. Machine learning techniques have now been applied successfully in a large number of environments, and their application to predicting the success of preclinical compounds could lead to a reduction in the attrition rate and therefore dramatic improvements to the cost of drug development.
The safety and quality of digitally-delivered health interventions
Researching regulation, standards, validation, and assessment of the efficacy, effectiveness, and costs of digital health.
(Pre-) adoption and abandonment of health innovations in different settings.
Evaluating facilitators and barriers influencing the uptake of digitally-delivered interventions from the perspective of different stakeholders (patients, carers, health workers, clinics, hospitals, policy makers, regulators, insurers, pharma, start-ups, medical device, biotech and technology companies etc.).
Sources of funding
UK Medical Research Council (MRC), GE Healthcare, CCRM, Sartorius Stedim Biotech (formerly TAP Biosystems), Lonza, CIRM, SENS Research Foundation, UK Cell Therapy Catapult, NIH Centre for Regenerative Medicine, NYSCF, ThermoFisher Scientific, Eisai, Medipost (US), Medipost (Korea), Celgene, Roche, Oxford Biomedica, Oxford NIHR BRU, the Saïd Foundation, the SENS Research Foundation, Innovate UK (formerly Technology Strategy Board), European Institute for Innovation and Technology (EIT) Health, Higher Education Funding Council for England (HEFCE), NHS England, UK Medical Research Council, European Institute for Innovation and Technology (EIT) Digital.