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Herpes simplex viruses (HSV) 1 and 2 are common infections affecting the global population. HSV 1 is the most common type estimated to affect 67% of the global population. HSV can have rare, but severe manifestations such as encephalitis and neonatal herpes necessitating the use of reliable and accurate diagnostic tools for the detection of the viruses. Currently used HSV diagnostic tools require highly specialized skills, availability of a laboratory setting and may lack sensitivity. More recent HSV diagnostic tools are numerous and need to be identified and compared in a systematic way to be able to make the best decision about which diagnostic tool to use. Diagnosis of HSV is essential for prompt treatment with antivirals. To select the best test for a patient, knowledge of the performance and limitations of each test are critical. This systematic review summarizes recent study articles evaluating HSV-1 and HSV-2 diagnostic tools.

Original publication




Journal article


JMIR Public Health and Surveillance


JMIR Publications