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Today, a range of products based on genomics, proteomics and metabolomics have facilitated the development of 'stratified' medicines and companion diagnostics. This investigation profiles a series of targeted medicines and corresponding diagnostics, and their role(s) in supporting evidence-based medicine. Despite their potential benefits we found that scientific, financial and regulatory barriers impede the development and adoption of companion diagnostics. Therefore, in order to realise improvements to the risk/benefit profiles of health-care interventions-notably reducing clinical uncertainty-conferred by the use of companion diagnostics, industry representatives, health-care providers and regulators will need a coordinated response to overcome these barriers.

Original publication

DOI

10.1038/tpj.2014.51

Type

Journal article

Journal

Pharmacogenomics J

Publication Date

02/2015

Volume

15

Pages

6 - 12

Keywords

Clinical Trials, Phase III as Topic, Drug Discovery, Drug Industry, Humans, Precision Medicine