Randomized clinical trial to evaluate the immunogenicity of quadrivalent meningococcal conjugate and polysaccharide vaccines in adults in the United kingdom.

Ramasamy MN., Clutterbuck EA., Haworth K., Bowman J., Omar O., Thompson AJ., Blanchard-Rohner G., Yu L-M., Snape MD., Pollard AJ.

Meningococcal conjugate vaccines are today successfully deployed in universal programs for children and adolescents in different geographic regions to control meningitis and septicemia. However, in adults, the advantages of these conjugates over the older polysaccharide vaccines are less clear. In this randomized clinical trial, we demonstrated that both conjugate and polysaccharide quadrivalent meningococcal vaccines elicit protective antibody responses in adults aged 18 to 70. (This study has been registered at www.clinicaltrials.gov under registration no. NCT00901940.).

DOI

10.1128/CVI.00099-14

Type

Journal article

Journal

Clin Vaccine Immunol

Publication Date

08/2014

Volume

21

Pages

1164 - 1168

Keywords

Adult, Aged, Antibodies, Bacterial, Antigens, Bacterial, Female, Humans, Male, Meningitis, Meningococcal, Meningococcal Vaccines, Middle Aged, Neisseria meningitidis, Polysaccharides, Bacterial, United Kingdom, Vaccination, Vaccines, Conjugate, Young Adult

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