Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Mouse models of intestinal inflammation resemble aspects of inflammatory bowel disease in humans. These models have provided important insights into mechanisms that control intestinal homeostasis and regulation of intestinal inflammation. This viewpoint discusses themes that have emerged from mouse models of intestinal inflammation including bacterial recognition, autophagy, the IL-23/Th-17 axis of inflammation as well as the role of negative regulators. Many of the pathways highlighted by model systems have been identified in recent genome-wide association studies in human validating the relevance of mouse models to human inflammatory bowel disease. Understanding of the complex biological mechanisms that lead to intestinal inflammation in mouse models may help to define targets for treatment of human diseases.

Original publication

DOI

10.1002/eji.200939602

Type

Journal article

Journal

Eur J Immunol

Publication Date

08/2009

Volume

39

Pages

2021 - 2026

Keywords

Animals, Bacteria, Disease Models, Animal, Gastroenteritis, Host-Pathogen Interactions, Humans, Inflammatory Bowel Diseases, Interleukin-10, Intestines, Mice, Models, Biological, Signal Transduction, T-Lymphocytes, Regulatory, Transforming Growth Factor beta