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Serogroup B Neisseria meningitidis is a frequent cause of invasive meningococcal disease, yet there are no effective vaccines suitable for routine immunisation. Limited efficacy has been shown with meningococcal outer membrane vacccines in children 4 years and older. Here we review the status of current research and consider new approaches to development of meningococcal serogroup B vaccines.


Journal article


Arch Dis Child

Publication Date





13 - 17


Bacterial Outer Membrane Proteins, Child, Clinical Trials, Phase II as Topic, Clinical Trials, Phase III as Topic, Exotoxins, Humans, Lipopolysaccharides, Meningitis, Meningococcal, Meningococcal Vaccines, Neisseria meningitidis