A large field study of typhoid conjugate vaccine (TCV) in Nepal has shown a single dose to be safe and effective in reducing typhoid in children aged 9 months to <16 years in an endemic setting.
Dr Sarah Atkinson\u2019s research team investigates whether an iron export mutation in African populations can protect from anaemia, malaria and bacterial infections.
Collaborative research between teams from the Department of Paediatrics and the Institut de Myologie shows how antisense oligonucleotides can penetrate muscles to treat myotonic dystrophy type 1, a rare muscle disease.
The University of Oxford and Harrington Discovery Institute at University Hospitals have announced a new affiliation to advance therapies for rare diseases. The joint program combines capabilities to improve treatment options globally for patients with rare diseases.
In a Medium interview, Professor Matthew Wood, a professor of Neuroscience in the Department of Paediatrics, talks about his work and the advances that a new Rare Diseases Centre could herald for the future of rare disease and genetics.
Work published in Current Biology shows that lightly brushing in an infant can reduce pain-related brain activity evoked by a clinically necessary medical procedure.
The Lancet has published the results of the Procedural Pain in Premature Infants (Poppi) study, ran by the Paediatric Neuroimaging Group and co-ordinated by the National Perinatal Epidemiology Unit (Clinical Trials Unit).
Dr Caroline Hartley, a Senior Postdoctoral Research Fellow in the Paediatric Neuroimaging Group, has been awarded the highly competitive Sir Henry Dale Fellowship.
The Paediatric Neuroimaging research team from the Department of Paediatrics at the University of Oxford will receive a \u00a3145,987 grant from Bliss, over three years, to fund a project which seeks to improve the measurement and treatment of pain in premature babies.
There are between 11 and 27 million estimated cases of enteric fever worldwide every year, and 75,000\u2013220,000 deaths. Could vaccination stop the spread of these diesases in the environment?
Dr Matthew Snape leads a study investigating if giving small amounts of oral insulin to babies can prevent type 1 diabetes, thus allowing mothers to protect their children from injecting insulin.
The recommendations result from research by Prof Irene Roberts (Department of Paediatrics) and Prof Paresh Vyas (Radcliffe Department of Medicine), published in the British Journal of Haematology.
Researchers are working with schools around the county to find 24,000 volunteers aged 16 to 18 years to take part in the Be on the TEAM (Teenagers Against Meningitis) trial, led by the Oxford Vaccine Group at the Oxford University's Paediatrics Department with funding and support from the National Institute for Health Research (NIHR).
Mildred Iro, a Paediatric Research Fellow working with the Oxford Vaccine Group, won the Lorber Prize for the best paediatric publication of 2017 for her work on childhood encephalitis admissions.
Typhoid fever, a bacterial infection that causes high fever, headache and other symptoms, remains a serious health problem in the developing world. It kills almost a quarter of a million people annually, and infects about 21 million.
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