Oligonucleotides - short DNA or RNA molecules - have great therapeutic application for a range of diseases. Yet, their potential has not been fully unleashed because of challenges linked to efficient delivery. Read more to find out about recent developments in oligonucleotide modifications, and the platforms that may be used to deliver them to target sites.
A new wearable \u2018bike helmet\u2019 style brain scanner, that allows natural movement during scanning, has been used in a study with young children for the first time. This marks an important step towards improving our understanding of brain development in childhood.
Dr Sarah Atkinson\u2019s research team investigates whether an iron export mutation in African populations can protect from anaemia, malaria and bacterial infections.
Collaborative research between teams from the Department of Paediatrics and the Institut de Myologie shows how antisense oligonucleotides can penetrate muscles to treat myotonic dystrophy type 1, a rare muscle disease.
In the latest issue of the Blueprint, Shaunna Latchman meets Professor of Paediatric Neuroimaging, Rebeccah Slater to discuss the Paediatric Neuroimaging Group and find out why a gentle touch really does goes a long way.
Work published in Current Biology shows that lightly brushing in an infant can reduce pain-related brain activity evoked by a clinically necessary medical procedure.
It is difficult to test whether painkillers work for very young children and we often don't know the best dose to give. But if Professor Rebeccah Slater and her research team at Oxford are successful we may find alternative ways to measure pain in babies and may eventually be able to offer babies some better options to soothe their pain.
Researchers from Oxford University's Department of Paediatrics have successfully completed the first human trial of a vaccine for a common virus that is particularly dangerous to infants.
The brains of babies \u2018light up\u2019 in a very similar way to adults when exposed to the same painful stimulus, a pioneering Oxford University brain scanning study has discovered. It suggests that babies experience pain much like adults.
The rapid evolution of HIV, which has allowed the virus to develop resistance to patients' natural immunity, is at the same time slowing the virus' ability to cause AIDS, according to new research Funded by the Wellcome Trust.
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