Polyglutamine expansion in the androgen receptor causes Kennedy's disease. Two recent reports, Cortes et al. (2014) in this issue of Neuron and Lieberman et al. (2014) in Cell Reports, raise the possibility that targeting expression of the mutant protein in skeletal muscle, instead of the nervous system, may mitigate manifestations of this disorder.
Journal article
2014-04-16T00:00:00+00:00
82
251 - 253
2
Animals, Brain, Humans, Male, Muscle, Skeletal, Muscular Disorders, Atrophic, Peptides, Receptors, Androgen