Self-supervised learning for a gene program-centric view of cell states

Moullet M., Isobe T., Vahidi A., Leonardi C., Paulas-Condori L., Soelistyo C., Steele L., Ly KCH., Quiroga Londono M., Mende N., Stephenson E., Iskander D., Webb S., Goh I., Vijayabaskar M., Liu Q., Jafree DJ., Asadollahzadeh H., Ramirez-Suastegui C., Merchant A., Roberts K., Rumney B., Chan HM., Holland A., Prete M., Horsfall D., Basurto-Lozada D., Lee JYW., Winheim E., Foster AR., Vilarrasa-Blasi R., Hannah R., Mahil SK., Smith C., Roy A., Roberts I., Laurenti E., Gottgens B., Vento-Tormo R., Haniffa M., Wilson NK., Lotfollahi M.

DOI

10.64898/2026.03.24.713961

Type

Preprint

Publication Date

2026-03-30T00:00:00+00:00

Keywords

3101 Biochemistry and Cell Biology, 31 Biological Sciences, Human Genome, Biotechnology, Stem Cell Research, Genetics, Data Science, Machine Learning and Artificial Intelligence, 1.1 Normal biological development and functioning, 2.1 Biological and endogenous factors, Inflammatory and immune system

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