Contact information
laurent.servais@paediatrics.ox.ac.uk
Fardowsi Kazi
fardowsi.kazi@paediatrics.ox.ac.uk
Laurent Servais
Professor of Paediatric Neuromuscular Diseases, Academic Director of the new Paediatric CRF
Biosketch
I am Professor of Paediatric Neuromuscular Diseases at the MDUK Oxford Neuromuscular Centre and Invited Professor of Child Neurology at Liège University.
After graduating from Louvain Medical School, Brussels, Belgium in 1999, I completed a PhD in Neuroscience (cerebellar electrophysiology in alert living mice) from Free University of Brussels, Belgium, followed by residencies in child neurology at the Free University of Brussels and Robert Debré Hospital, Paris. In 2008, I took a position in neuromuscular disease and clinical research at the Institute of Myology in Paris, where my interest and expertise in neuromuscular diseases flourished. I was subsequently appointed Head of Clinical Trials and Database Services. Most recently, I served as Head of the Institute of Myology’s I-Motion (Institute Of Muscle-Oriented Translational Innovation), and Head of the Neuromuscular Centre in Liège, Belgium. I have joined MD UK Oxford Neuromuscular Center and the University of Oxford in September 2019.
I have been involved as principal investigator in numerous clinical trials to test treatments for Duchenne muscular dystrophy and spinal muscular atrophy (SMA).
I am the leader of the newborn screening program for SMA in southern Belgium where we are conducting a medico-economic analysis of newborn screening. My main research expertise covers the development of innovative outcome measures, including connected devices for real-life patients’ evaluation.
Recent publications
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Efficacy and safety of onasemnogene abeparvovec in children with spinal muscular atrophy type 1: real-world evidence from 6 infusion centres in the United Kingdom
Journal article
Gowda V. et al, (2024), The Lancet Regional Health - Europe, 37
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Real-World Outcomes in Patients with Spinal Muscular Atrophy Treated with Onasemnogene Abeparvovec Monotherapy: Findings from the RESTORE Registry.
Journal article
Servais L. et al, (2024), J Neuromuscul Dis, 11, 425 - 442
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The Importance of Early Treatment of Inherited Neuromuscular Conditions.
Journal article
Mackels L. and Servais L., (2024), J Neuromuscul Dis, 11, 253 - 274
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Pathogenic DPAGT1 variants in limb-girdle congenital myasthenic syndrome (LG-CMS) associated with tubular aggregates and ORAI1 hypoglycosylation.
Journal article
Brande LV. et al, (2023), Neuropathol Appl Neurobiol
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Cost-effectiveness of spinal muscular atrophy newborn screening based on real-world data in Belgium.
Journal article
Dangouloff T. et al, (2023), Neuromuscul Disord, 34, 61 - 67