Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Epidemiological and immunological evidence suggests that some vaccines can reduce all-cause mortality through nonspecific changes made to innate immune cells. Here, we present the first data to describe the nonspecific immunological impact of oral vaccination with live-attenuated Salmonella Typhi strain Ty21a. We vaccinated healthy adults with Ty21a and assessed aspects of innate and adaptive immunity over the course of 6 months. Changes to monocyte phenotype/function were observed for at least 3 months. Changes to innate and adaptive immune cell cytokine production in response to stimulation with vaccine and unrelated nonvaccine antigens were observed over the 6-month study period. The changes that we have observed could influence susceptibility to infection through altered immune responses mounted to subsequently encountered pathogens. These changes could influence all-cause mortality.

Original publication

DOI

10.1126/sciadv.aau6849

Type

Journal article

Journal

Sci Adv

Publication Date

02/2019

Volume

5

Keywords

Administration, Oral, Adult, CD4-Positive T-Lymphocytes, Cytokines, Female, Healthy Volunteers, Humans, Male, Middle Aged, Monocytes, Polysaccharides, Bacterial, Salmonella typhi, Typhoid Fever, Typhoid-Paratyphoid Vaccines, Vaccination, Vaccines, Attenuated, Young Adult